Cyclooxygenase inhibitors and cancer: the missing pieces

C Patrono - Journal of Pharmacology and Experimental …, 2023 - ASPET
cyclooxygenase-2 inhibitors. A single placebo-controlled randomized trial of aspirin has shown
long-term colorectal cancerchemopreventive effect of aspirin and other cyclooxygenase …

[HTML][HTML] The role of cyclooxygenase-2 in colorectal cancer

J Sheng, H Sun, FB Yu, B Li, Y Zhang… - International journal of …, 2020 - ncbi.nlm.nih.gov
… (CRC) is the second most frequent deadly cancer in the United State. The proposed …
Etiologically, colon cancer is caused by spread of colorectal cancer cells to other parts of the body. …

Targeting cyclooxygenase-2 for chemoprevention of inflammation-associated intestinal carcinogenesis: An update

KS Chun, EH Kim, DH Kim, NY Song, W Kim… - Biochemical …, 2024 - Elsevier
colorectal cancer and several other malignancies. The association between chronic inflammation
and cancer has been revisited: cancer … drugs during the cancer chemopreventive trials. …

[HTML][HTML] Cyclooxygenase 2-regulated genes an alternative avenue to the development of new therapeutic drugs for colorectal cancer

AM Hidalgo-Estévez, K Stamatakis… - Frontiers in …, 2020 - frontiersin.org
… or PGs in colon carcinoma lines and overexpressed in colon … roles of those molecules in
colon cancer in the context of PG/… inhibitors, providing alternative approaches in colon cancer. …

[HTML][HTML] Non-steroidal anti-inflammatory drugs and biomarkers: A new paradigm in colorectal cancer

G Rashid, NA Khan, D Elsori, A Rehman… - Frontiers in …, 2023 - frontiersin.org
… Targeting the molecules (COX-2 cyclooxygenase 2, NF-kB, VEGF) involved in the … a few
NSAIDs such as aspirin, sulindac, and celecoxib and colorectal cancer chemoprevention was …

A Contemporary Review on the Critical Role of Nonsteroidal Anti-inflammatory Agents in Colorectal Cancer Therapy

…, F Ghasemi, A Sahebkar - Anti-Cancer Agents …, 2024 - ingentaconnect.com
… This makes them potential candidates for chemoprevention of several malignancies,
particu… colon adenomas. So, they can serve as one of the best combinations in colon cancer

[HTML][HTML] A systematic review of the cyclooxygenase-2 (COX-2) expression in rectal cancer patients treated with preoperative radiotherapy or radiochemotherapy

M Berbecka, A Forma, J Baj… - Journal of Clinical …, 2021 - mdpi.com
… of the cyclooxygenase-2 (COX-2) in rectal cancer treated with … of preoperative treatment of
rectal cancer with regards to the … , and Scopus databases on 1 January 2021 with the usage …

[HTML][HTML] In Vitro Inhibition of Colorectal Cancer Gene Targets by Withania somnifera L. Methanolic Extracts: A Focus on Specific Genome Regulation

JM Macharia, DO Pande, A Zand, F Budán… - Nutrients, 2024 - mdpi.com
… , and B-cell lymphoma 2) in colon cancer cell lines (Caco-2 … of caspase-9 genes and the
inhibition of cyclooxygenase-2, 5-… WS as a promising natural inhibitor of colorectal cancer (CRC) …

[HTML][HTML] Perspectives of the application of non-steroidal anti-inflammatory drugs in cancer therapy: Attempts to overcome their unfavorable side effects

V Thiruchenthooran, E Sánchez-López, A Gliszczyńska - Cancers, 2023 - mdpi.com
… activity mainly by blocking cyclooxygenase-2 involved in the … before cancer induction
confirmed their chemopreventive … 2279 colon cancer patients and 2907 non-colon cancer patients …

[HTML][HTML] Looking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention

A Ozleyen, YB Yilmaz, S Donmez, HN Atalay… - Journal of Cancer …, 2023 - Springer
… rise and fall of highly selective cyclooxygenase-2 (COX-2) inhibitors and the latest …
chemopreventive use of NSAIDs in patients with genetic susceptibility to colon carcinoma could be …